M2 Pyruvate Kinase

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M2PK is a sensitive screening test for colon and rectal cancer, used prior to confirmation by colonoscopy.  Colorectal cancer is one of the most common malignancies, accounting for about 11% of all deaths from cancer.

It is recommended that everyone over the age of 50, without pre-existing risk factors, be screened for colon cancer.

The concentration of M2PK in the faeces correlates with the severity of colorectal cancer. It has a sensitivity of 81% and a specificity of 80%.

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